Endocrine Abstracts

Introduction: Only <1% of cases of primary hyperparathyroidism (PHPT) occur during pregnancy. PHPT increases risk of complications such as miscarriage, premature birth and life-threatening maternal hypercalcemic crises. Hyperparathyroidism Jaw Tumor Syndrome (HPT-JT) is a rare inherited cause of PHPT, resulting from CDC73 gene mutations. There are a few reports described about HPT-JT in pregnancy. Although parathyroidectomy is the definite treatment for PHPT, given the sca...

Introduction: There have been more than 130 genes described in relation with the development of obesity, which condition hyperphagia and early obesity. The aim of this study is to determine the prevalence of genetic alterations in a cohort of patients with morbid obesity.Materials and Methods: We designed a descriptive cross-sectional study for a cohort of subjects with obesity grade III or higher (BMI ≥40 kg/m2), treated at endocrinolog...

Objectives: To determine the lifestyle in patients with morbid obesity in a previous group and in a group after performing bariatric surgery.Material and methods: Cross-sectional study in two groups of patients with morbid obesity one before and one after bariatric surgery attended in the Clinical Management Unit of Endocrinology and Nutrition of the Puerta del Mar Hospital in Cádiz. The clinical and analytical data of the patients, the sociodemogra...

Pituitary stalk interruption syndrome (PSIS) is a rare clinical entity characterised by an absent or thin pituitary stalk, hypoplasia of the anterior pituitary gland, and ectopic location of the posterior pituitary on magnetic resonance imaging (MRI). Presentation is on early childhood or puberty and the most common hormonal deficiencies are growth hormone (GH) and gonadotropines. We present the case of a 28-year-old female patient who consulted after 2 years in secondary amen...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare condition (1–2% of causes for hypercalcemia) and may be confused with primary hyperparathyroidism. Diagnosis of FHH must be suspected in patients with a family history of chronic hypercalcemia, no symptoms and low urinary excretion. This disease is due to mutations in the calcium-sensing receptor (CASR) gene. Meningiomas are common intracranial tumors (15–20% of primary neoplasms of the central nervou...

Objectives: To evaluate the prevalence in our work center of pathology of adrenal glands and to assess the efficacy of the radiology imaging in the detection of especific features and to exclude malignancy lessions.Material and Methods: We included patients who presented some adrenal lesion with histological study after surgerie between January 2010 and December 2015 in the hospitals of Albacete, Almansa and Villarrobledo. We use the Pathological Anatomy...

Introduction: Recent advance of genetic testing has contributed to the diagnosis of hereditary pheochromocytoma and paraganglioma (PPGL). Germline mutations in MYC associated factor X(MAX) are responsible for 1.1% of these PPGL; the median age at onset is 33 years and no reliable penetrance estimation is available for MAX-carriers. The authors present the case of a synchronous bilateral pheochromocytoma that prompted the discovery of a proband of MAX mutation and three other r...

Introduction: Recent studies suggest that the use of dipeptidyl peptidase 4 inhibitors (DPP-4i) may be associated with an increased risk of developing bullous pemphigoid; which has led to publication of several pharmacovigilance alerts.Objectives: To characterize the potential association between the use of DPP-4i and the risk of developing bullous pemphigoid.Material & methods: Observational, retrospective study based on clini...

Introduction: There are known biological differences between men and women in coronary heart disease. It is important to know these differences in order to avoid inequalities in prevention, diagnosis and treatment of this pathology.Methods: We designed a retrospective, descriptive study in which we included all diabetic patients admitted to 3 different hospitals in Cádiz province with acute coronary syndrome and diabetes in 2016. Demographic data an...

Objectives: To evaluate the psychosocial aspects in a group of patients in follow-up in specific consultation of bariatric surgery prior to the intervention and in a group of patients intervened.Methods: Cross-sectional study of patients in follow-up in the specific morbid obesity consultation of the University Hospital Puerta del Mar (Cádiz) not intervened and a group intervened and in a group intervened, at 6–12 months of follow-up.<p cla...